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KMID : 0981820070270020128
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Korean Journal of Laboratory Medicine
2007 Volume.27 No. 2 p.128 ~ p.132
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Clinical Significance of Serum Interleukin-18 Concentration in the Patients with Atopic Dermatitis
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Park Do-Sim
Youn Young-Hoon
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Abstract
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Background : Interleukin (IL)-18, a potent inducer of interferon gamma (IFN- ), is known to have a role in diseases involving type-2 T helper cell responses including atopic dermatitis. In this study, we aimed to determine the clinical significance of serum IL-18 level in the patients with atopic dermatitis.
Methods : Serum concentration of IL-18, IFN- , IgE, and blood eosinophil were measured in the patients with atopic dermatitis and healthy control subjects, and their association with the clinical score of the disease was analysed.
Results : Serum concentrations of IL-18 were significantly elevated in patients with atopic dermatitis compared to the healthy controls (332 pg/mL vs 151 pg/mL, P<0.05). Serum levels of IL-18 (r=0.41, P=0.001), eosinophil (r=0.36, P=0.003), and IgE (r=0.32, P=0.009) correlated with clinical scores in the patients. Also, multiple regression analysis indicated that serum IL-18 and IgE levels were independent predictors for the clinical score of atopic dermatitis (r2=0.25, =0.39, P=0.001 and =0.32, P=0.009).
Conclusions : Our results confirmed a significant correlation between the concentration of serum IL-18 and the severity of atopic dermatitis. Although serum IL-18 concentration reflects the disease severity, its usefulness as a clinical test needs to be further investigated, because its additive benefit over those of conventional blood tests is not evident so far. (Korean J Lab Med 2007;27:128-32)
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KEYWORD
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Interleukin 18, Atopic dermatitis, Cytokine
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